diff --git a/adafruit_pioasm.py b/adafruit_pioasm.py
index fa5a529..cf7f7e5 100644
--- a/adafruit_pioasm.py
+++ b/adafruit_pioasm.py
@@ -58,6 +58,8 @@ class Program:  # pylint: disable=too-few-public-methods
         wrap = None
         wrap_target = None
         offset = -1
+        pio_version = 0
+
         for i, line in enumerate(text_program.split("\n")):
             line = line.strip()
             if not line:
@@ -68,6 +70,8 @@ class Program:  # pylint: disable=too-few-public-methods
                 if program_name:
                     raise RuntimeError("Multiple programs not supported")
                 program_name = line.split()[1]
+            elif line.startswith(".pio_version"):
+                pio_version = int(line.split()[1], 0)
             elif line.startswith(".origin"):
                 offset = int(line.split()[1], 0)
             elif line.startswith(".wrap_target"):
@@ -247,6 +251,9 @@ class Program:  # pylint: disable=too-few-public-methods
         if offset != -1:
             self.pio_kwargs["offset"] = offset
 
+        if pio_version != 0:
+            self.pio_kwargs["pio_version"] = pio_version
+
         if sideset_count != 0:
             self.pio_kwargs["sideset_pin_count"] = sideset_count
 
diff --git a/tests/pytest_helpers.py b/tests/pytest_helpers.py
index 72ac7cf..8425a5b 100644
--- a/tests/pytest_helpers.py
+++ b/tests/pytest_helpers.py
@@ -45,4 +45,6 @@ def assert_assembly_fails(
 
 def assert_pio_kwargs(source: str, **kw: Any) -> None:
     program = adafruit_pioasm.Program(source)
-    assert kw == program.pio_kwargs
+    assert (
+        kw == program.pio_kwargs
+    ), f"Assembling {source!r}: Expected {kw}, got {program.pio_kwargs}"
diff --git a/tests/test_version.py b/tests/test_version.py
new file mode 100644
index 0000000..82717e8
--- /dev/null
+++ b/tests/test_version.py
@@ -0,0 +1,15 @@
+# SPDX-FileCopyrightText: 2024 Jeff Epler, written for Adafruit Industries
+#
+# SPDX-License-Identifier: MIT
+
+"""
+Tests version dependent instructions
+"""
+
+from pytest_helpers import assert_pio_kwargs, assert_assembly_fails
+
+
+def test_version() -> None:
+    assert_pio_kwargs(".pio_version 0", sideset_enable=0)
+    assert_pio_kwargs(".pio_version 1", pio_version=1, sideset_enable=0)
+    assert_assembly_fails(".pio_version muffin", errtype=ValueError)