diff --git a/tests/drivers/entropy/api/entropy_psa_crypto.conf b/tests/drivers/entropy/api/entropy_psa_crypto.conf
new file mode 100644
index 00000000000..9abeaac408c
--- /dev/null
+++ b/tests/drivers/entropy/api/entropy_psa_crypto.conf
@@ -0,0 +1,4 @@
+CONFIG_TFM_PARTITION_CRYPTO=y
+CONFIG_TFM_CRYPTO_RNG_MODULE_ENABLED=y
+CONFIG_ENTROPY_PSA_CRYPTO_RNG=y
+CONFIG_HARDWARE_DEVICE_CS_GENERATOR=y
diff --git a/tests/drivers/entropy/api/entropy_psa_crypto.overlay b/tests/drivers/entropy/api/entropy_psa_crypto.overlay
new file mode 100644
index 00000000000..bc4a4afc116
--- /dev/null
+++ b/tests/drivers/entropy/api/entropy_psa_crypto.overlay
@@ -0,0 +1,16 @@
+/*
+ * Copyright (c) 2022 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/ {
+	chosen {
+		zephyr,entropy = &rng_psa;
+	};
+
+	rng_psa: entropy_psa_crypto {
+		compatible = "zephyr,psa-crypto-rng";
+		status = "okay";
+	};
+};
diff --git a/tests/drivers/entropy/api/testcase.yaml b/tests/drivers/entropy/api/testcase.yaml
index 8c38ab084ee..879ff73aa24 100644
--- a/tests/drivers/entropy/api/testcase.yaml
+++ b/tests/drivers/entropy/api/testcase.yaml
@@ -6,3 +6,7 @@ tests:
     platform_allow: nrf52_bsim
     extra_args: DTC_OVERLAY_FILE=./entropy_bt_hci.overlay OVERLAY_CONFIG=./entropy_bt_hci.conf
     tags: driver entropy bluetooth
+  drivers.entropy.psa_crypto:
+    filter: CONFIG_BUILD_WITH_TFM
+    extra_args: DTC_OVERLAY_FILE=./entropy_psa_crypto.overlay OVERLAY_CONFIG=./entropy_psa_crypto.conf
+    tags: driver entropy psa-crypto