diff --git a/drivers/i2s/Kconfig.nrfx b/drivers/i2s/Kconfig.nrfx
index 1cb023a2b2e..b36f3eb9c64 100644
--- a/drivers/i2s/Kconfig.nrfx
+++ b/drivers/i2s/Kconfig.nrfx
@@ -6,6 +6,7 @@ menuconfig I2S_NRFX
 	default y
 	depends on DT_HAS_NORDIC_NRF_I2S_ENABLED
 	select NRFX_I2S0 if HAS_HW_NRF_I2S0
+	select NRFX_I2S20 if HAS_HW_NRF_I2S20
 	select PINCTRL
 	help
 	  Enable support for nrfx I2S driver for nRF MCU series.
diff --git a/drivers/i2s/i2s_nrfx.c b/drivers/i2s/i2s_nrfx.c
index 57910c464ab..e1b3684c4f7 100644
--- a/drivers/i2s/i2s_nrfx.c
+++ b/drivers/i2s/i2s_nrfx.c
@@ -955,5 +955,10 @@ static const struct i2s_driver_api i2s_nrf_drv_api = {
 			 POST_KERNEL, CONFIG_I2S_INIT_PRIORITY,		     \
 			 &i2s_nrf_drv_api);
 
-/* Existing SoCs only have one I2S instance. */
+#ifdef CONFIG_HAS_HW_NRF_I2S0
 I2S_NRFX_DEVICE(0);
+#endif
+
+#ifdef CONFIG_HAS_HW_NRF_I2S20
+I2S_NRFX_DEVICE(20);
+#endif