diff --git a/samples/boards/nrf/nrf53_sync_rtc/net/prj.conf b/samples/boards/nrf/nrf53_sync_rtc/net/prj.conf
index 3dab7fc3a4b..48abb73c344 100644
--- a/samples/boards/nrf/nrf53_sync_rtc/net/prj.conf
+++ b/samples/boards/nrf/nrf53_sync_rtc/net/prj.conf
@@ -1,6 +1,5 @@
 CONFIG_LOG=y
 CONFIG_NRF53_SYNC_RTC=y
 CONFIG_MBOX=y
-CONFIG_MBOX_NRFX_IPC=y
 
 CONFIG_IPM=n
diff --git a/samples/boards/nrf/nrf53_sync_rtc/prj.conf b/samples/boards/nrf/nrf53_sync_rtc/prj.conf
index bd3897e65a6..d71e10102f4 100644
--- a/samples/boards/nrf/nrf53_sync_rtc/prj.conf
+++ b/samples/boards/nrf/nrf53_sync_rtc/prj.conf
@@ -3,4 +3,3 @@ CONFIG_LOG=y
 CONFIG_NRF53_SYNC_RTC=y
 CONFIG_IPM=n
 CONFIG_MBOX=y
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/drivers/mbox/boards/nrf5340dk_nrf5340_cpuapp.conf b/samples/drivers/mbox/boards/nrf5340dk_nrf5340_cpuapp.conf
index 83d68d06b26..569f94a19a5 100644
--- a/samples/drivers/mbox/boards/nrf5340dk_nrf5340_cpuapp.conf
+++ b/samples/drivers/mbox/boards/nrf5340dk_nrf5340_cpuapp.conf
@@ -1,2 +1 @@
-CONFIG_MBOX_NRFX_IPC=y
 CONFIG_SOC_NRF53_CPUNET_ENABLE=y
diff --git a/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf b/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
index 665e456f504..e57e7e2174f 100644
--- a/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
+++ b/samples/drivers/mbox/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
@@ -1,2 +1 @@
-CONFIG_MBOX_NRFX_IPC=y
 CONFIG_BUILD_OUTPUT_EXE=n
diff --git a/samples/drivers/mbox/remote/boards/nrf5340dk_nrf5340_cpunet.conf b/samples/drivers/mbox/remote/boards/nrf5340dk_nrf5340_cpunet.conf
deleted file mode 100644
index a1ab15fae14..00000000000
--- a/samples/drivers/mbox/remote/boards/nrf5340dk_nrf5340_cpunet.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/icmsg/boards/nrf5340dk_nrf5340_cpuapp.conf b/samples/subsys/ipc/ipc_service/icmsg/boards/nrf5340dk_nrf5340_cpuapp.conf
index fdcda87bff6..569f94a19a5 100644
--- a/samples/subsys/ipc/ipc_service/icmsg/boards/nrf5340dk_nrf5340_cpuapp.conf
+++ b/samples/subsys/ipc/ipc_service/icmsg/boards/nrf5340dk_nrf5340_cpuapp.conf
@@ -1,2 +1 @@
 CONFIG_SOC_NRF53_CPUNET_ENABLE=y
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/icmsg/remote/boards/nrf5340dk_nrf5340_cpunet.conf b/samples/subsys/ipc/ipc_service/icmsg/remote/boards/nrf5340dk_nrf5340_cpunet.conf
deleted file mode 100644
index a1ab15fae14..00000000000
--- a/samples/subsys/ipc/ipc_service/icmsg/remote/boards/nrf5340dk_nrf5340_cpunet.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/multi_endpoint/boards/nrf5340dk_nrf5340_cpuapp.conf b/samples/subsys/ipc/ipc_service/multi_endpoint/boards/nrf5340dk_nrf5340_cpuapp.conf
index fdcda87bff6..569f94a19a5 100644
--- a/samples/subsys/ipc/ipc_service/multi_endpoint/boards/nrf5340dk_nrf5340_cpuapp.conf
+++ b/samples/subsys/ipc/ipc_service/multi_endpoint/boards/nrf5340dk_nrf5340_cpuapp.conf
@@ -1,2 +1 @@
 CONFIG_SOC_NRF53_CPUNET_ENABLE=y
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/multi_endpoint/remote/boards/nrf5340dk_nrf5340_cpunet.conf b/samples/subsys/ipc/ipc_service/multi_endpoint/remote/boards/nrf5340dk_nrf5340_cpunet.conf
deleted file mode 100644
index a1ab15fae14..00000000000
--- a/samples/subsys/ipc/ipc_service/multi_endpoint/remote/boards/nrf5340dk_nrf5340_cpunet.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/static_vrings/boards/nrf5340dk_nrf5340_cpuapp.conf b/samples/subsys/ipc/ipc_service/static_vrings/boards/nrf5340dk_nrf5340_cpuapp.conf
index fdcda87bff6..569f94a19a5 100644
--- a/samples/subsys/ipc/ipc_service/static_vrings/boards/nrf5340dk_nrf5340_cpuapp.conf
+++ b/samples/subsys/ipc/ipc_service/static_vrings/boards/nrf5340dk_nrf5340_cpuapp.conf
@@ -1,2 +1 @@
 CONFIG_SOC_NRF53_CPUNET_ENABLE=y
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/ipc/ipc_service/static_vrings/remote/boards/nrf5340dk_nrf5340_cpunet.conf b/samples/subsys/ipc/ipc_service/static_vrings/remote/boards/nrf5340dk_nrf5340_cpunet.conf
deleted file mode 100644
index a1ab15fae14..00000000000
--- a/samples/subsys/ipc/ipc_service/static_vrings/remote/boards/nrf5340dk_nrf5340_cpunet.conf
+++ /dev/null
@@ -1 +0,0 @@
-CONFIG_MBOX_NRFX_IPC=y
diff --git a/samples/subsys/logging/multidomain/boards/nrf5340bsim_nrf5340_cpuapp.conf b/samples/subsys/logging/multidomain/boards/nrf5340bsim_nrf5340_cpuapp.conf
index f14ca9ebc20..7dd30059e69 100644
--- a/samples/subsys/logging/multidomain/boards/nrf5340bsim_nrf5340_cpuapp.conf
+++ b/samples/subsys/logging/multidomain/boards/nrf5340bsim_nrf5340_cpuapp.conf
@@ -1,4 +1,3 @@
-CONFIG_MBOX_NRFX_IPC=y
 # For the mailbox to be initialized logger initialization is delayed like in real HW
 CONFIG_LOG_PROCESS_THREAD=y
 CONFIG_LOG_MODE_DEFERRED=y
diff --git a/samples/subsys/logging/multidomain/boards/nrf5340dk_nrf5340_cpuapp.conf b/samples/subsys/logging/multidomain/boards/nrf5340dk_nrf5340_cpuapp.conf
index 41ee9e5e3f2..c4bcfada790 100644
--- a/samples/subsys/logging/multidomain/boards/nrf5340dk_nrf5340_cpuapp.conf
+++ b/samples/subsys/logging/multidomain/boards/nrf5340dk_nrf5340_cpuapp.conf
@@ -1,5 +1,4 @@
 CONFIG_SOC_NRF53_CPUNET_ENABLE=y
-CONFIG_MBOX_NRFX_IPC=y
 CONFIG_LOG_BACKEND_UART_ASYNC=y
 CONFIG_UART_ASYNC_API=y
 CONFIG_UART_0_ASYNC=y
diff --git a/samples/subsys/logging/multidomain/remote/boards/nrf5340bsim_nrf5340_cpunet.conf b/samples/subsys/logging/multidomain/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
index 2d6de6e7c7c..58323e53a3f 100644
--- a/samples/subsys/logging/multidomain/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
+++ b/samples/subsys/logging/multidomain/remote/boards/nrf5340bsim_nrf5340_cpunet.conf
@@ -1,4 +1,3 @@
-CONFIG_MBOX_NRFX_IPC=y
 CONFIG_BUILD_OUTPUT_EXE=n
 # For the mailbox to be initialized logger initialization is delayed like in real HW
 CONFIG_LOG_PROCESS_THREAD=y
diff --git a/samples/subsys/logging/multidomain/remote/boards/nrf5340dk_nrf5340_cpunet.conf b/samples/subsys/logging/multidomain/remote/boards/nrf5340dk_nrf5340_cpunet.conf
index cb04b37b233..b7b68aa249f 100644
--- a/samples/subsys/logging/multidomain/remote/boards/nrf5340dk_nrf5340_cpunet.conf
+++ b/samples/subsys/logging/multidomain/remote/boards/nrf5340dk_nrf5340_cpunet.conf
@@ -1,2 +1 @@
-CONFIG_MBOX_NRFX_IPC=y
 CONFIG_MPU_STACK_GUARD=y